133440-66-1

Basic information

• Product Name: 4-(5-amino-6-hydroxy-2-benzoxazolyl)-benzoic acid
• Synonyms: 4-(5-amino-6-hydroxy-2-benzoxazolyl)-benzoic acid;4-(5-Amino-6-hydroxybenzo[d]oxazol-2-yl)benzoic acid
• CAS NO: 133440-66-1
• Molecular Formula: C14H10N2O4
• Molecular Weight: 270.2402
• Mol File: 133440-66-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 506.7°Cat760mmHg
• Flash Point: 260.2°C
• Appearance: /
• Density: 1.517g/cm³
• Vapor Pressure: 4.34E-11mmHg at 25°C
• Refractive Index: 1.744
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(5-amino-6-hydroxy-2-benzoxazolyl)-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-amino-6-hydroxy-2-benzoxazolyl)-benzoic acid(133440-66-1)
• EPA Substance Registry System: 4-(5-amino-6-hydroxy-2-benzoxazolyl)-benzoic acid(133440-66-1)

Safety Data

• Hazardous Substances Data: 133440-66-1(Hazardous Substances Data)

Usage

General Description

4-(5-amino-6-hydroxy-2-benzoxazolyl)-benzoic acid, also known as AHBA, is a chemical compound with potential medicinal and pharmaceutical applications. It is a derivative of salicylic acid and is commonly used as a key intermediate in the synthesis of various antibiotics, such as rifamycin and ansamycin. AHBA has been found to possess antibacterial and antitumor properties, making it a valuable building block in the development of new drugs. Additionally, it has been studied for its potential as a fluorescent label for protein in biotechnology and medical imaging. Overall, AHBA is a versatile and important chemical compound with diverse applications in medicine and science.

InChI:InChI=1/C14H10N2O4/c15-9-5-10-12(6-11(9)17)20-13(16-10)7-1-3-8(4-2-7)14(18)19/h1-6,17H,15H2,(H,18,19)

Upstream product

• 133554-24-2 methyl 4-(6-hydroxy-5-nitrobenzo[d]oxazol-2-yl)benzoate 
• 133532-53-3 4-(5-nitro-6-hydroxybenzoxazol-2-yl)benzoic acid 

Relevant articles and documents

4-(5-Amino-6-Hydroxybenzoxazol-2-YL) Ammonium Benzoate and Preparation Method and Use Thereof

Disclosed in the present invention are 4-(5-amino-6-hydroxybenzoxazol-2-yl)ammonium benzoate shown in formula (I) and the preparation method and use thereof. The preparation method comprises: fully reacting 4-(5-amino-6-hydroxybenzoxazol-2-yl)benzoic acid shown in formula (II) or 4-(5-amino-6-hydroxybenzoxazol-2-yl)carboxamide benzoate, as a raw material, with ammonia in an aqueous solvent, and directly heating the obtained reaction liquid to remove excess ammonia, so as to obtain 4-(5-amino-6-hydroxybenzoxazol-2-yl)ammonium benzoate. The mass of the 4-(5-amino-6-hydroxybenzoxazol-2-yl)ammonium benzoate (ABAA) prepared in the present invention can reach a polymer grade (where the purity is above 99.5%, the content of metal ions is below 200 ppm, and containing no DMF polymerization inhibition impurities), and the 4-(5-amino-6-hydroxybenzoxazol-2-yl)ammonium benzoate can be used as an AB type monomer for preparing PBO and modified PBO fibres, the resulting PBO having an intrinsic viscosity n of up to 38/dl/g, and the method has such features as ABAA being highly soluble in PPA, a fast polymerization speed, a short time of 2-4 h, a low temperature of 150° C., a high molecular weight of the polymer, fibres of excellent tensile property, being easy to industrialize, etc.