1334412-55-3

Basic information

• Product Name: tert-butyl 3-fluoro-4-(hydroxyMethyl)-4-Methylpiperidine-1-carboxylate
• Synonyms: tert-butyl 3-fluoro-4-(hydroxyMethyl)-4-Methylpiperidine-1-carboxylate
• CAS NO: 1334412-55-3
• Molecular Formula: C12H22FNO3
• Molecular Weight: 247.3063832
• Mol File: 1334412-55-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 3-fluoro-4-(hydroxyMethyl)-4-Methylpiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-fluoro-4-(hydroxyMethyl)-4-Methylpiperidine-1-carboxylate(1334412-55-3)
• EPA Substance Registry System: tert-butyl 3-fluoro-4-(hydroxyMethyl)-4-Methylpiperidine-1-carboxylate(1334412-55-3)

Safety Data

• Hazardous Substances Data: 1334412-55-3(Hazardous Substances Data)

Usage

General Description

Tert-butyl 3-fluoro-4-(hydroxyMethyl)-4-Methylpiperidine-1-carboxylate is a chemical compound with the molecular formula C14H25FNO3. It is a piperidine derivative with a tert-butyl ester group, a fluoro substituent, and a hydroxymethyl group attached to a methyl group on the piperidine ring. tert-butyl 3-fluoro-4-(hydroxyMethyl)-4-Methylpiperidine-1-carboxylate is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It may also have potential application in medicinal chemistry research due to its unique structural features and potential biological activity.

Relevant articles and documents

A 1 - R1 - 3, 3 - difluoro (or 3 - fluoro) - 4 - R2 - 4 - aminomethyl piperidine and its derivatives

The invention relates to a preparation method for 1-R1-3,3-difluoro(or3-fluoro)-4-R2-4-aminomethylpiperidine shown as a formula (1-A) and a formula (1-B) and derivatives thereof. In the formulas, R1 is hydrogen, C1-C9 alkyl, aryl, benzyl, CF3CO, R5CO or R6OCO; R5 is C1-C9 alkyl, aryl or benzyl; R6 is C1-C9 alkyl, aryl or benzyl; R2 is C1-C9 alkyl, aryl or benzyl; R3 is hydrogen, C1-C9 alkyl, aryl, benzyl, CF3CO, R5CO or R6OCO; R4 is hydrogen, C1-C9 alkyl, aryl, benzyl, CF3CO, R5CO or R6OCO; and the above optional groups are not substituted or substituted by a group consisting of one or more selected from alkyl, haloalkyl, hydroxyalkyl, halogen, alkyloxy or hydroxyl. The preparation method is novel, raw materials and reagents are cheap, the reaction conditions are mild, the operation is easy and simple, and generated 1-R1-3,3-difluoro(or3-fluoro)-4-R2-4-aminomethylpiperidine and the derivatives thereof can be used as important intermediates of new drug research and development.