1334419-70-3Relevant articles and documents
An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit
Deng, Xianming,Zhou, Wenjun,Weisberg, Ellen,Wang, Jinhua,Zhang, Jianming,Sasaki, Takaaki,Nelson, Erik,Griffin, James D.,Jaenne, Pasi A.,Gray, Nathanael S.
, p. 4579 - 4584 (2012/08/07)
Here we describe the synthesis and characterization of a number of 3-amino-1H-indazol-6-yl-benzamides that were designed to target the 'DFG-out' conformation of the kinase activation loop. Several compounds such as 4 and 11 exhibit single-digit nanomolar EC50s against FLT3, c-Kit and the gatekeeper T674M mutant of PDGFRα.