1334419-76-9

Basic information

• Product Name: C₃₂H₃₃F₃N₆O₂
• Synonyms: C₃₂H₃₃F₃N₆O₂
• CAS NO: 1334419-76-9
• Molecular Weight: 590.648
• Mol File: 1334419-76-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₂H₃₃F₃N₆O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₂H₃₃F₃N₆O₂(1334419-76-9)
• EPA Substance Registry System: C₃₂H₃₃F₃N₆O₂(1334419-76-9)

Safety Data

• Hazardous Substances Data: 1334419-76-9(Hazardous Substances Data)

Upstream product

• 105942-08-3 4-bromo-6-fluorobenzonitrile 
• 1334419-89-4 ethyl 3-(3-(cyclopropanecarboxamido)-1H-indazol-6-yl)benzoate 
• 1334419-88-3 N-(6-bromo-1H-indazol-3-yl)cyclopropanecarboxamide 
• 630125-91-6 4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethylphenylamine 
• 404827-77-6 ethyl 3-(3-(cyclopropanecarboxamido)-1H-indazol-6-yl)benzoate 

Relevant articles and documents

An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit

Here we describe the synthesis and characterization of a number of 3-amino-1H-indazol-6-yl-benzamides that were designed to target the 'DFG-out' conformation of the kinase activation loop. Several compounds such as 4 and 11 exhibit single-digit nanomolar EC50s against FLT3, c-Kit and the gatekeeper T674M mutant of PDGFRα.