1334440-85-5Relevant academic research and scientific papers
Regioselective threefold aromatic substitution of benzoic acid derivatives by dearomatization, regioselective functionalization, and rearomatization
Koch, Eva,Studer, Armido
, p. 4933 - 4936 (2013)
Ipso, meta, and para: Benzoic acid derivatives can be highly regioselectively substituted at the ipso, meta, and para positions. The reaction sequence comprises an alkylative Birch reduction, a 4-alkylation, a palladium-catalyzed γ-arylation, and an oxidative rearomatization (see scheme). All the reactions are robust and experimentally easy to conduct. Copyright
Stereospecific palladium-catalyzed decarboxylative C(sp3)- C(sp2) Coupling of 2,5-Cyclohexadiene-1-carboxylic Acid Derivatives with Aryl Iodides
Chou, Chih-Ming,Chatterjee, Indranil,Studer, Armido
supporting information; experimental part, p. 8614 - 8617 (2011/11/05)
Walk on the same side! The title reaction occurs by means of highly stereospecific 1,3-metal migration. The starting carboxylic acids are readily prepared by Birch reduction, and the developed protocol provides an efficient route to enantiomerically pure
