1334446-34-2

Upstream product

• 588-07-8 3-Chloroacetanilide 
• 73568-33-9 2,7-dichloro-quinoline-3-carbaldehyde 
• 1334446-26-2 (2,7-dichloroquinolin-3-yl)methyl 4-methylbenzenesulfonate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1017464-12-8 3-(hydroxymethyl)-2,7-dichloroquinoline 

Downstream Products

• 1391868-26-0 ethyl 4-(4-((2,7-dichloroquinolin-3-yl)methoxy)phenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylate 
• 1334446-42-2 (Z)-5-([4-(2,7-dichloroquinolin-3-yl)methoxy]benzylidine)thiazolidine-2,4-dione 

Relevant academic research and scientific papers

Synthesis of New dihydropyrimidinones catalysed by dicationic ionic Liquid

A convenient multi step synthetic protocol for new dihydropyrimidinones bearing quinolynyl methoxy phenyl moiety has been developed from 2-chloro-3-formyl quinolines. The last step is one-pot Biginelli reaction of multicomponents, 4-((2-chloroquinolin-3-yl) methoxy) benzaldehydes, ethyl acetoacetate and urea mediated and catalysed by dicationic ionic liquid (3-methyl-1-[3-(methyl-1H-imidazolium-1-yl) propyl]- 1H-imidazolium dibromide (C3 [min]2 2 [Br-] )). Simple work-up procedures and moderate to good yields of the pyrimidinones and the intermediates are the merits of the route. Indian Academy of Sciences.

Synthetic Route for New (Z)-5-[4-(2-Chloroquinolin-3-yl) Methoxy]benzylidinethiazolidine-2,4-diones

Synthetic route has been developed for the synthesis of new (Z)-5-[4-(2-chloroquinolin-3-yl) methoxy]benzylidinethiazolidine-2,4-diones (6a-h) starting from 2-chloro-3-hydroxymethyl quinolines (2a-h). The hydroxy methyl quinolines on tosylation yielded (3a-h). Condensation of the tosyl intermediates with 4-hydroxy benzaldehydes has been carried in DMF in presence of K2CO3 and obtained 4-quinolinyl methoxy benzaldehydes (4a-h). Conveniently Knoevenagel condensation of quinolinyl methoxy benzaldehydes (4a-h) and 2, 4-thiazolidinedione (5) has been carried in PEG-400 in presence of L-proline and obtained better yields of the titled compounds (6a-h).