133446-11-4Relevant academic research and scientific papers
Metal Complexes of Biologically Important Ligands, LX. Metal Complexes of 3'-Azido-3'-desoxythymidine (AZT) und 3'-Isocyano-3'-deoxythymidine
Pill, Thomas,Polborn, Kurt,Kleinschmidt, Andrea,Erfle, Volker,Breu, Walter,et al.
, p. 1541 - 1548 (2007/10/02)
Metal complexes of N-3-deprotonated 3'-azido-3'-deoxythymidine (AZT- H+), (AZT - H+)AuPR3 (R = Me, Et, Ph) (2, 3, 4), trans-(AZT-H+)2Pd(NH3)2 (5), +)M(μ-Cl)2M(AZT - H+)(n-Bu3P)> (M = Pd, Pt) (6, 7), trans-(Ph3P)2Pd(AZT - H+)2 (8), cis-(Ph3P)2Pt(AZT - H+)(Cl) (9), and complexes of 3'-isocyano-3'-deoxythymidine (L), (Et3P)(L)-PdCl2 (11), (12), (n-Bu3P)(L)PtCl2 (13), (BF4) (14), (η5-C5Me5)(L)RhCl2 (15), and (η5-C5Me5)(L)IrCl2 (16) have been prepared and characterized by IR and NMR spectra, 2 by X-ray crystallography. 2, 4, and 9 show an anti-HIV activity very similar to AZT; 2 exhibits antiinflammatory activity. Key Words: Gold complexes / Palladium complexes / Platinum complexes / Rhodium complexes / Iridium complexes / 3'-Azido-3'-deoxythymidine / 3'-Isocyano-3'-deoxythymidine / Anti-HIV / Antiinflammatory activity
