Cas 1334469-72-5,3-(benzo[d][1,3]dioxol-5-yl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-(4-methylpiperidin-1-yl)propan-1-one

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Check Digit Verification of cas no

The CAS Registry Mumber 1334469-72-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,4,4,6 and 9 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1334469-72:
(9*1)+(8*3)+(7*3)+(6*4)+(5*4)+(4*6)+(3*9)+(2*7)+(1*2)=165
165 % 10 = 5
So 1334469-72-5 is a valid CAS Registry Number.

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1334469-72-5Relevant academic research and scientific papers

Identification of potent and selective diphenylpropanamide RORγ inhibitors

Huh, Jun R.,Englund, Erika E.,Wang, Hang,Huang, Ruili,Huang, Pengxiang,Rastinejad, Fraydoon,Inglese, James,Austin, Christopher P.,Johnson, Ronald L.,Huang, Wenwei,Littman, Dan R.

, p. 79 - 84 (2013/03/13)

Retinoic acid-related orphan receptor RORγt plays a pivotal role in the differentiation of TH17 cells. Antagonizing RORγt transcriptional activity is a potential means to treat TH17-related autoimmune diseases. Herein, we describe the identification of a series of diphenylpropanamides as novel and selective RORγ antagonists. Diphenylpropanamide 4n inhibited the transcriptional activity of RORγt, but not RORα, in cells. In addition, it suppressed human TH17 cell differentiation at submicromolar concentrations.

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