1334474-17-7

Basic information

• Product Name: 3-acetyl-1-(4-chlorophenyl)-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one
• Synonyms: 3-acetyl-1-(4-chlorophenyl)-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one
• CAS NO: 1334474-17-7
• Molecular Weight: 351.789
• Mol File: 1334474-17-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-acetyl-1-(4-chlorophenyl)-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-acetyl-1-(4-chlorophenyl)-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one(1334474-17-7)
• EPA Substance Registry System: 3-acetyl-1-(4-chlorophenyl)-2-methyl-4-oxa-1-azacyclopenta[a]naphthalen-5-one(1334474-17-7)

Safety Data

• Hazardous Substances Data: 1334474-17-7(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 123-54-6 acetylacetone 
• 51218-07-6 4-(4-chlorophenylamino)pent-3-en-2-one 

Relevant articles and documents

Environment dependent photophysical and fluorescence turn-off sensing properties of Fe(iii) by substituted phenyl isochromenopyrrol-5-ones

Analogues of isochromenopyrrolone were synthesized using Montomorillonite K10 as a catalyst and characterized. The electronic structure and geometry of all the synthesized compounds were investigated experimentally by UV-visible absorption and fluorescence spectroscopy. A negligible shift was observed in the absorption spectrum while a large red shift was observed in the fluorescence spectrum upon changing from non-polar to polar solvents. The experimental results were compared with those from density functional theory calculations. The observed photophysical properties were induced from the solvent environment. Except for chlorosubstituition, other functional groups like methyl, dimethyl, diethyl or methoxy, did not influence the electronic properties of the molecules significantly. The experimental results were in good agreement with the theoretical interpretations. Moreover, these isochromenopyrrolones possess excellent sensing ability for Fe(iii) ions via the fluorescence turn-off mechanism with a detection limit of ～10-6 M and an association constant of ～103 M-1. It is proposed that these molecules can find their use in environment sensing applications.

Facile synthesis of substituted pyrrole-fused isocoumarins from ninhydrin

A simple and efficient procedure has been developed for the synthesis of substituted pyrrole-fused isocoumarins from easily available ninhydrin. The cyclic hemiaminal dihydroxy-indenopyrroles, the adducts of ninhydrin with enamines of acetylacetone, give pyrrole-fused isocoumarins upon heating in acidic medium. The process constitutes an interesting acid-catalyzed rearrangement to eight-membered lactams followed by intramolecular cyclization involving the amino and keto groups.