1334481-84-3

Usage

Uses

Used in Pharmaceutical Synthesis:
t-Butyl ((3R,4S)-4-Methylpyrrolidin-3-yl)carbamate is used as a key intermediate in the synthesis of more complex pharmaceutical compounds. Its unique stereochemistry and functional groups make it a valuable building block for creating novel drugs with potential therapeutic applications.
Used in Antibacterial Agents:
In the field of antibacterial drug development, t-Butyl ((3R,4S)-4-Methylpyrrolidin-3-yl)carbamate is used as a reactant and precursor in the preparation of antibacterial agents. Its incorporation into the molecular structure of these agents can enhance their efficacy against bacterial infections by targeting specific bacterial enzymes or processes, potentially leading to the development of new antibiotics to combat drug-resistant bacteria.

Upstream product

• 127199-52-4 (3S,4S)-1-benzyl-3-(tert-butoxycarbonyl)amino-4-methylpyrrolidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 178899-79-1 (2S,3R)-2-amino-3-methylbutane-1,4-diol 
• 149598-21-0 (2S,3R)-2-(tert-butoxycarbonyl)amino-3-methylbutane-1,4-diol 
• 149598-23-2 (2S,3R)-2-(tert-butoxycarbonyl)amino-1,4-bis(methanesulfonyloxy)-3-methylbutane 
• 178755-12-9 (2S,3R-)-2-[N-Benzyl-N-(9-phenylfluoren-9-yl)]amino-3-methylbutane-1,4-diol 
• 869956-21-8 (3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-(phenylsulfanil)methylpyrrolidine 
• 181230-28-4 1-benzyl-3(S)-[(t-butoxycarbonyl)amino] - 4(R)-methylpyrrolidine 
• 174847-52-0 1-benzyl-3(S)-[(t-butoxycarbonyl)amino]-4(R)-methylpyrrolidine 
• 150336-29-1 1-benzyl-3(R)-[(t-butoxycarbonyl)amino] - 4(S)-methylpyrrolidine 
• 74880-20-9 3(S)-amino-l-benzyl-4(S)-methylpyrrolidine 

Downstream Products

• 1610704-01-2 benzyl (3R,4S)-3-((tert-butoxycarbonyl)amino)-4-methylpyrrolidine-1-carboxylate 
• 1610704-00-1 (3S,4R)-3-tert-butoxycarbonyl-4-methylpyrrolidine-1-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

SUBSTITUTED PYRROLIDINE DERIVATIVE

The present invention contemplates provision of a quinolone antibacterial agent and a drug for the treatment of infectious diseases, which exhibit potent antibacterial activity and higher selective toxicity against Gram-positive and Gram-negative bacteria

Quinoline carboxylic acid

5-Amino-7-((3S,4S)-3-amino-4-methyl (or ethyl)-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid or a pharmacologically acceptable salt thereof represented by the following formula wherein asymmetric carbon atoms

Phenyloxazolidinone antimicrobials

The present invention relates to antimicrobial phenyloxazolidinone compounds having a pyrrolidinyl or azetidinyl moiety.

A large-scale preparation of (3S,4S)-3-(tert-butoxycarbonyl)amino-4-methylpyrrolidine and its analogs from L-aspartic acid

(3S,4S)-3-(tert-Butoxycarbonyl)amino-4-methylpyrrolidine (12a) was synthesized from L-aspartic acid (4) on a large scale. Methylation of dimethyl (2S)-N-benzyl-N-(9-phenylfluoren-9-yl)aspartate (5), easily derived from 4, with methyl iodide gave (3R)-3-methylaspartate (6a) in 91% yield with high diastereoselectivity. Reduction of 6a with lithium aluminum hydride, followed by hydrogenolysis, protection with di-tert-butyl dicarbonate, and mesylation gave 10a in 89% overall yield. Subsequently, reaction of 10a with benzylamine under a nitrogen atmosphere at room temperature, followed by hydrogenolysis, gave the target compound (12a) in 65% overall yield. In a similar manner to that described for the preparation of 12a from 5, compound 5 was converted into 4-ethyl and 4-propyl derivatives (12b,c) in 34% and 38% overall yields.

Optically active pyridonecarboxylic acid derivatives

N1 -(1,2-cis-2-halogenocyclopropyl)-substituted pyridonecarboxylic acid derivatives represented by the following formula (I) the terms of which are defined in the specification and the salts thereof are disclosed: STR1 These compounds have pate

Isoindoline derivatives

Optically active 8-methoxyquinolonecarboxylic acids represented by the formula (I) wherein R1 is lower alkyl have been found to possess potent antibacterial activity against both Gram-negative and Gram-positive bacteria. The compounds may be synthesized from novel optically active intermediates.

1-cyclopropyl-6-fluoro-8-alkyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives

Novel 4-oxoquinoline-3-carboxylic acid compounds of the formula: STR1 wherein R2 is 1-pyrrolidinyl which may have 1 to 2 substituents selected from the group consisting of (i) C1 -C6 alkyl, (ii) amino-(C1 -Csub

Pyridonecarboxylic acid derivatives and antibacterial pharmaceutical compositions thereof

Pyridonecarboxylic acid derivatives of the following formula, STR1 wherein R is hydrogen atom or lower alkyl group, R1 is lower alkyl group, cycloalkyl group or haloalkyl group, Y is hydrogen atom or halogen atom, or Y and R1 are STR