1334482-22-2Relevant academic research and scientific papers
Pseudo-five-component reaction between 3-formylchromones, Meldrum's acid, isocyanides and primary arylamines: Diversity-oriented synthesis of novel chromone-containing peptidomimetics
Teimouri, Mohammad Bagher,Akbari-Moghaddam, Peyman,Golbaghi, Golara
, p. 659 - 666 (2011)
An efficient and practical method has been developed for the diversity-oriented synthesis of chromone-containing tripeptides via pseudo-five-component reaction between 3-formylchromones, Meldrum's acid, isocyanides and primary aromatic amines for the generation of a wide range of structurally interesting and pharmacologically significant compounds at ambient temperature. It is worth mentioning that in the course of this reaction, five new bonds (two C-C bonds, two C-N bonds and one C=O bond) are formed. In the present reaction three amide bonds are newly formed.
