1334512-17-2Relevant academic research and scientific papers
CuH-Catalyzed Asymmetric Reduction of α,β-Unsaturated Carboxylic Acids to β-Chiral Aldehydes
Zhou, Yujing,Bandar, Jeffrey S.,Liu, Richard Y.,Buchwald, Stephen L.
supporting information, p. 606 - 609 (2018/01/26)
The copper hydride (CuH)-catalyzed enantioselective reduction of α,β-unsaturated carboxylic acids to saturated aldehydes is reported. This protocol provides a new method to access a variety of β-chiral aldehydes in good yields, with high levels of enantioselectivity and broad functional group tolerance. A reaction pathway involving a ketene intermediate is proposed based on preliminary mechanistic studies and density functional theory calculations.
Copper-catalyzed asymmetric allylic substitution of allyl phosphates with aryl- and alkenylboronates
Shintani, Ryo,Takatsu, Keishi,Takeda, Momotaro,Hayashi, Tamio
, p. 8656 - 8659 (2011/11/06)
The asymmetric allylic substitution of allyl phosphates with aryl- and alkenylboronates catalyzed by a copper/N-heterocyclic carbene complex was developed and the substitution products were obtained with high enantioselectivity (see scheme). To account for the observed influence of the reaction parameters a possible catalytic cycle for this process was proposed. Copyright
