1334551-22-2

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 61148-36-5 4-Hydrazinotetrazolo<1,5-a>chinoxalin 
• 2213-63-0 2,3-dichloroquinoxaline 
• 15804-19-0 quinoxaline-2,3-dione 
• 95-54-5 1,2-diamino-benzene 
• 59866-06-7 4-Chloro-tetrazolo[1,5-a]quinoxaline 

Downstream Products

• 1334551-42-6 2-(4-trifluoromethylphenyl)-3-(tetrazolo[1,5-a]quinoxalin-4-ylamino)-1,3-thiazolidin-4-one 
• 1334551-32-4 3-chloro-4-(4-trifluoromethylphenyl)-1-(tetrazolo[1,5-a]quinoxalin-4-ylamino)azetidin-2-one 

Relevant academic research and scientific papers

Synthesis of tetrazolo[1,5-a]quinoxaline based azetidinones & thiazolidinones as potent antibacterial & antifungal agents

4-Chlorotetrazolo[1,5-a]quinoxaline (III) was synthesized by azide (2+3) cycloaddition of 2,3-dichloroquinoxaline (II). Compound (III) on further refluxing with hydrazine hydrate furnished 4-hydrazinotetrazolo[1,5- a]quinoxaline (IV). Further refluxing of (IV) with different aromatic aldehydes in methanol yielded corresponding Schiff's bases V(a-j). Various 4-aminotetrazolo[1,5-a]quinoxaline based azetidinones VII(a-j) were synthesized by stirring the compounds V(a-j), at low temperature, with equimolar mixture of chloroacetylchloride & triethylamine in dry benzene, while 4-aminotetrazolo[1,5-a]quinoxaline based thiazolidinones VIII(a-j) were synthesized by refluxing Schiff's bases V(a-j) with thioglycolic acid in oil-bath. The structures of all the compounds were confirmed on the basis of 1H-NMR & FT-IR spectral data. All the newly synthesized compounds were screened for in-vitro antimicrobial activity against E. coli, S. aureus, K. pneumoniae & P. aeruginosa & antifungal activity against C. albicans. Few of them have exhibited the promising activity.