1334590-76-9Relevant articles and documents
Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting d-Glu- and diphosphate-binding sites
Tomasic, Tihomir,Kovac, Andreja,Simcic, Mihael,Blanot, Didier,Grdadolnik, Simona Golic,Gobec, Stanislav,Kikelj, Danijel,Peterlin Masic, Lucija
, p. 3964 - 3975 (2011/10/31)
Mur ligases are involved in cytoplasmic steps of bacterial peptidoglycan biosynthesis and are viable targets for antibacterial drug discovery. We have designed and synthesized a focused chemical library of compounds combining the glutamic acid moiety and