1334611-91-4Relevant academic research and scientific papers
Design and synthesis of inhibitors of noroviruses by scaffold hopping
Dou, Dengfeng,Mandadapu, Sivakoteswara Rao,Alliston, Kevin R.,Kim, Yunjeong,Chang, Kyeong-Ok,Groutas, William C.
experimental part, p. 5749 - 5755 (2011/10/31)
A scaffold hopping strategy was employed to identify new chemotypes that inhibit noroviruses. The replacement of the cyclosulfamide scaffold by an array of heterocyclic scaffolds lead to the identification of additional series of compounds that possessed anti-norovirus activity in a cell-based replicon system.
