1334629-97-8Relevant academic research and scientific papers
New phenylaminopyrimidine (PAP) anticancer lead compound with high efficacy: Design, synthesis, and in vitro screening
El-Deeb, Ibrahim Mustafa,Han, Dong Keun,Kim, In Tae,Lee, So Ha
experimental part, p. 1848 - 1858 (2010/12/24)
Phenylaminopyrimidines represent a large group of new selective anticancer agents, the majority of which exert their action through the inhibition of specific kinases. In this study, a new series of N-substituted-2- aminopyrimidines has been designed and synthesized. A selected group of the synthesized derivatives was screened at a single dose concentration of 10 μM over a panel of 60 cancer cell-lines. Compound 12e has showed great inhibitory and strong lethal effect over almost all of the 60 cell-lines and accordingly was further tested in a 5-dose testing mode to determine its IC50 values, where it showed great efficacies with intermediate potencies over the tested cell-lines. The compound was also tested over a panel of 52 kinases to explore its kinase inhibitory profile, and was found to be a selective but moderate inhibitor over FLT3 kinase.
