133464-91-2 Usage
Role
Reagent for protecting carbonyl groups in organic molecules
Application
Synthesis of pharmaceuticals and other complex organic compounds
Protecting group
tert-butyldimethylsilyl (TBDMS)
Function of protecting group
Blocks the reactivity of hydroxyl and carbonyl groups in organic molecules for selective and controlled reactions
Importance
An important tool in the field of organic chemistry for protecting carbonyl groups during synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 133464-91-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,4,6 and 4 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 133464-91:
(8*1)+(7*3)+(6*3)+(5*4)+(4*6)+(3*4)+(2*9)+(1*1)=122
122 % 10 = 2
So 133464-91-2 is a valid CAS Registry Number.
133464-91-2Relevant academic research and scientific papers
Oxygenation of Silyl Enol Ethers and Silyl Ketene Acetals with Molecular Oxygen and Aldehyde Catalyzed by Nickel(II) Complex. A Convenient Method for the Preparation of α-Hydroxy Carbonyl Compounds
Takai, Toshihiro,Yamada, Tohru,Rhode, Oliver,Mukaiyama, Teruaki
, p. 281 - 284 (2007/10/02)
In the presence of a catalytic amount of nickel(II) complex, silyl enol ethers and silyl ketene acetals are smoothly oxygenated by the combined use of molecular oxygen and aldehyde to afford α-siloxy carbonyl compounds via possible intermediates, siloxy epoxides.And on treatment of the α-siloxy carbonyl compounds with potassium fluoride α-hydroxy carbonyl compounds are obtained in good to high yields.
