1334667-66-1Relevant articles and documents
Synthesis and biological evaluation of novel 1,2,3-triazole derivatives as anti-tubercular agents
Aziz Ali, Abdul,Gogoi, Dhrubajyoti,Chaliha, Amrita K.,Buragohain, Alak K.,Trivedi, Priyanka,Saikia, Prakash J.,Gehlot, Praveen S.,Kumar, Arvind,Chaturvedi, Vinita,Sarma, Diganta
, p. 3698 - 3703 (2017)
A library of seventeen novel 1,2,3-triazole derivatives were efficiently synthesized in excellent yields by the popular ‘click chemistry’ approach and evaluated in vitro for their anti-tubercular activity against Mycobacterium tuberculosis H37Ra (ATCC 25177 strain). Among the series, six compounds exhibited significant activity with minimum inhibitory concentration (MIC) values ranging from 3.12 to 0.78?μg/mL and along with no significant cytotoxicity against MBMDMQs (mouse bone marrow derived macrophages). Molecular docking of the target compounds into the active site of DprE1 (Decaprenylphosphoryl-β-D-ribose-2′-epimerase) enzyme revealed noteworthy information on the plausible binding interactions.