1334680-47-5

Upstream product

• 5153-67-3 nitrostyrene 
• 557-20-0 diethylzinc 
• 94-41-7 benzalacetophenone 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 102-96-5 (2-nitroethenyl)benzene 
• 16460-86-9 (S)-1,3-diphenylpentan-1-one 

Downstream Products

• 1334680-76-0 (3R,4S)-3,5-diphenyl-4-((S)-1-phenylpropyl)-3,4-dihydro-2H-pyrrole 
• 1334680-79-3 (2R,3S,4R)-2,4-diphenyl-3-((S)-1-phenylpropyl)pyrrolidine 
• 1334680-78-2 (2R,3S,4S)-3-benzoyl-2,4-diphenylhexanoic acid 
• 1334680-81-7 (2R,3S,4S)-3-benzyl-2,4-diphenylhexanoic acid 

Relevant academic research and scientific papers

Copper-catalyzed asymmetric tandem double Michael reactions of diethylzinc to α,β-unsaturated ketones followed by trapping with nitroolefins

A copper catalyzed asymmetric tandem double Michael addition of diethylzinc to α,β-unsaturated ketones followed by trapping with nitroolefins has been developed using chiral P,N-ligands. The tandem products were obtained in good yields and excellent enantioselectivities with three contiguous stereocenters.

Highly enantioselective tandem double Michael reactions catalyzed by Ni(acac)2/(+)-MINBOL complex

An in situ prepared complex of chiral ligand (+)-MINBOL 1 and Ni(acac)2 (12.5 mol % and 0.5 mol % respectively) can efficiently catalyze enantioselective tandem double Michael reactions. In this reaction, aryl or alkyl nitroalkenes were employed as electrophiles. The corresponding tandem adducts were obtained in good yields and with high enantioselectivities (up to 97% ee).

Highly diastereo- and enantioselective tandem reaction toward functionalized pyrrolidines with multiple stereocenters

An efficient asymmetric tandem dual Michael reaction that constructs three contiguous stereocenters in acyclic open-chain systems with very high enantioselectivity and diastereoselectivity has been developed. This protocol provides a reliable and rapid ap