1334680-83-9Relevant academic research and scientific papers
Mechanistic investigations of palladium-catalyzed allylic fluorination
Katcher, Matthew H.,Norrby, Per-Ola,Doyle, Abigail G.
, p. 2121 - 2133 (2014/06/09)
A computational and experimental approach was employed to study the mechanism of the palladium(0)-catalyzed fluorination of allylic chlorides with AgF as fluoride source. Our findings indicate that an allylpalladium fluoride is a key intermediate necessar
Palladium-catalyzed regio- and enantioselective fluorination of acyclic allylic halides
Katcher, Matthew H.,Sha, Allen,Doyle, Abigail G.
, p. 15902 - 15905 (2011/11/13)
This report describes the Pd(0)-catalyzed fluorination of linear allylic chlorides and bromides, yielding branched allylic fluorides in high selectivity. Many of the significant synthetic limitations previously associated with the preparation of these products are overcome by this catalytic method. We also demonstrate that a chiral bisphosphine-ligated palladium catalyst enables highly enantioselective access to a class of branched allylic fluorides that can be readily diversified to valuable fluorinated products.
