1334723-43-1Relevant articles and documents
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates
Youngsaye, Willmen,Vincent, Benjamin,Hartland, Cathy L.,Morgan, Barbara J.,Buhrlage, Sara J.,Johnston, Stephen,Bittker, Joshua A.,MacPherson, Lawrence,Dandapani, Sivaraman,Palmer, Michelle,Whitesell, Luke,Lindquist, Susan,Schreiber, Stuart L.,Munoz, Benito
, p. 5502 - 5505 (2011)
The effectiveness of the potent antifungal drug fluconazole is being compromised by the rise of drug-resistant fungal pathogens. While inhibition of Hsp90 or calcineurin can reverse drug resistance in Candida, such inhibitors also impair the homologous hu