1334758-82-5Relevant articles and documents
Synthesis and evaluation of the metabolites of AMG 221, a clinical candidate for the treatment of type 2 diabetes
Li, Aiwen,Yuan, Chester C.,Chow, David,Chen, Michelle,Emery, Maurice G.,Hale, Clarence,Zhang, Xiping,Subramanian, Raju,St. Jean, David J.,Komorowski, Renee,Veniant, Murielle,Wang, Minghan,Fotsch, Christopher
, p. 824 - 827 (2012/01/06)
All eight of the major active metabolites of (S)-2-((1S,2S,4R)-bicyclo[2.2. 1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221, compound 1), an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 that has entered the clinic for the treatm