1334791-75-1Relevant academic research and scientific papers
Metal-free, Regio-, and Stereo-Controlled Hydrochlorination and Hydrobromination of Ynones and Ynamides
Zeng, Xiaojun,Lu, Zhichao,Liu, Shiwen,Hammond, Gerald B.,Xu, Bo
, p. 13179 - 13187 (2017/12/26)
We developed an atom-economical and metal-free method for the regio- and stereo-selective hydrohalogenation of ynones and ynamides using easy to handle DMPU/HX (X = Br or Cl) reagents. The reaction operates under mild conditions and a range of functional groups is well tolerated. We propose that the hydrohalogenation of ynones gives the anti-addition products via a concerted multimolecular AdE3 mechanism and that the hydrohalogenation of ynamides produces the syn-addition products via a cationic keteniminium intermediate.
Selective and CO-retentive addition reactions of acid chlorides to terminal alkynes in synthesis of β-Chloro-α,β-unsaturated ketones using ZnO
Hosseini-Sarvari, Mona,Mardaneh, Zahra
experimental part, p. 778 - 782 (2011/08/22)
The addition reaction of acid chlorides with terminal alkynes to afford β-Chloro-α,β-unsaturated ketones using ZnO as catalyst has been studied under solvent-free conditions. All the reactions were done at room temperature and β-Chloro-α,β-unsaturated ket
