1334849-09-0

Basic information

• Product Name: dimethyl 3-(2-chlorophenyl)-1',3'-dioxo-1',3'-dihydrospiro(cyclopropane-1,2'-indene)-2,2-dicarboxylate
• Synonyms: dimethyl 3-(2-chlorophenyl)-1',3'-dioxo-1',3'-dihydrospiro(cyclopropane-1,2'-indene)-2,2-dicarboxylate
• CAS NO: 1334849-09-0
• Molecular Weight: 398.799
• Mol File: 1334849-09-0.mol

Chemical Properties

• CAS DataBase Reference: dimethyl 3-(2-chlorophenyl)-1',3'-dioxo-1',3'-dihydrospiro(cyclopropane-1,2'-indene)-2,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 3-(2-chlorophenyl)-1',3'-dioxo-1',3'-dihydrospiro(cyclopropane-1,2'-indene)-2,2-dicarboxylate(1334849-09-0)
• EPA Substance Registry System: dimethyl 3-(2-chlorophenyl)-1',3'-dioxo-1',3'-dihydrospiro(cyclopropane-1,2'-indene)-2,2-dicarboxylate(1334849-09-0)

Safety Data

• Hazardous Substances Data: 1334849-09-0(Hazardous Substances Data)

Upstream product

• 15875-56-6 2-(2-chloro-benzylidene)-indan-1,3-dione 
• 868-26-8 dimethyl 2-bromomalonate 

Relevant articles and documents

Synthesis of activated cyclopropanes by an MIRC strategy: An enantioselective organocatalytic approach to spirocyclopropanes

An efficient cyclopropanation, by a Michael-initiated ring-closing (MIRC) reaction of 2-arylidene-1,3-indandiones and 2-arylidene malononitriles, has been developed by using different α-monohalogenated methylene active compounds with triethylamine. The first enantioselective cyclopropanation to spirocyclopropanes derived by the reaction of 2-arylidene-1,3-indandiones and dimethyl bromomalonate with a commercially available α,α-L- diarylprolinol as the organocatalyst and K2CO3 as the additive has been accomplished. The spirocyclopropanes were isolated in high yield and up to 85% ee. Notably, the asymmetric one-pot sequential approach to spirocyclopropanes proved to be a feasible process. A simple triethylamine-promoted domino cyclopropanation of 2-arylidene-1,3-indandiones and 2-arylidenemalononitriles with α-monohalogenated methylene-active compounds has been efficiently developed. Spirocyclopropanes derived from 2-arylidene-1,3-indandiones were synthesized with up to 85% ee by using dimethyl bromomalonate and α,α-L-diarylprolinol/K2CO3 system. Copyright