133487-95-3

Upstream product

• 77800-70-5 2,6-Diethoxy-4-ethoxycarbonyl-7-phenyl-3H-azepin-3-one 
• 77800-63-6 (1R,5S)-3,7-Diethoxy-4-oxo-1-phenyl-2-aza-bicyclo[3.2.0]hept-2-ene-5-carboxylic acid ethyl ester 
• 73197-59-8 6-Ethoxy-4-ethoxycarbonyl-3-hydroxy-7-phenyl-1,5-dihydro-2H-azepin-2-one 
• 77800-66-9 3,7-Diethoxy-5-ethoxycarbonyl-6-hydroxy-2-phenyl-4H-azepine 
• 77800-63-6 dl-(1R*,5S*,7R*)-3,7-diethoxy-5-ethoxycarbonyl-1-phenyl-2-azabicyclo<3.2.0>hept-2-en-4-one 
• 60769-87-1 rel-(1S,5R,7R)-7-ethoxy-5-ethoxycarbonyl-1-phenyl-2-azabicyclo<3.2.0>heptane-3,4-dione 

Relevant academic research and scientific papers

2-AZABICYCLOHEPTANE-3,4-DIONES (3): LEWIS ACID CATALYSED RING EXPANSION OF 3-ETHOXY-Δ2-AZABICYCLOHEPTAN-4-ONES: SYNTHESIS OF 2-ETHOXY-3-AZATROPONES

Treatment of 2-azabicycloheptane-3,4-dione imidic ester (6) with tin(IV) chloride gave the dihydroazatropolone 2-ethyl ethers (7) in moderate yields which were also obtained by reaction of dihydroazatropolones (2) with Meerwein reagent.DDQ oxidation of 7 gave 2-ethoxy-3-azatropones (8), which rearranged, on treatment with water, into ethyl pyridine 2-carboxylate (10).Spectroscopic data of azatropolone 2-ethyl ethers were also described.