133488-39-8 Usage
Chemical structure
A compound consisting of a pyrimidine base linked to a sugar molecule.
Classification
Nucleoside analog.
Structural similarity
Similar in structure to the building blocks of RNA and DNA.
Pharmaceutical applications
Potential use in antiviral and antibacterial medications, as well as in the treatment of certain types of cancer.
Mechanism of action
Ability to interfere with the replication of viral and bacterial DNA.
Research applications
May have applications in the field of molecular biology and biochemistry for research purposes.
Pyrimidine base
A nitrogen-containing heterocyclic compound that forms the basis of the molecule.
Sugar molecule
A 2,3-dideoxy-alpha-L-threo-hexofuranosyl unit, which is a modified sugar structure.
Amino group
A 3-amino group attached to the sugar molecule.
Methyl group
A 5-methyl group attached to the pyrimidine base.
Dione functional group
A 2,4(1H,3H)-dione group, which is a carbonyl group attached to the pyrimidine base.
Stereochemistry
The compound has a specific stereochemistry, with the sugar molecule being in the alpha-L-threo configuration.
Check Digit Verification of cas no
The CAS Registry Mumber 133488-39-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,4,8 and 8 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 133488-39:
(8*1)+(7*3)+(6*3)+(5*4)+(4*8)+(3*8)+(2*3)+(1*9)=138
138 % 10 = 8
So 133488-39-8 is a valid CAS Registry Number.
133488-39-8Relevant articles and documents
Synthesis of 3′-azolyl-2′,3′-dideoxyhexose nucleosides
Walczak, Krzysztof,Pedersen, Erik B.,Nielsen, Claus
, p. 935 - 941 (2007/10/03)
1,8-Diazabicyclo[5.4.0]undec-7-ene salts of 2-methyl-4(5)-nitroimidazole or benzotriazole were obtained in crystalline form. Michael-type addition of these salts to (45,5R)-(E)-4,6-di-O-acetyl-5-hydroxy-2-hexenal gave, after acetylation of the product, an isomeric mixture of acetylated 3-(azol-1-yl)-2,3-dideoxy-D-arabino-hexopyranosides and 3-(azol-1-yl)-2,3-dideoxy-D-ribo-hexofuranosides. Reaction of these peracetylated adducts with trimethylsilylated thymine in the presence of trimethylsilyl trifluoromethanesulfonate (TMS Inflate) afforded the corresponding nucleosides which were deprotected by using methanolic ammonia. The nucleosides were found inactive against HIV-1 and HSV-1. Acta Chemica Scandinavica 1998.
