133489-81-3

Upstream product

• 2786-02-9 2-lithiofuran 
• 115766-13-7 (S)-α-[[(1,1-dimethylethoxy)carbonyl]amino]-N-methoxy-N-methylcyclohexanepropanamide 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 37736-82-6 (S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid 

Downstream Products

• 141258-96-0 (4S-cis)-4-cyclohexylmethyl-5-(2-furanyl)-2-oxazolidinone 
• 133660-33-0 (4S-trans)-4-(cyclohexylmethyl)-5-(2-furanyl)-2-oxazolidinone 
• 133489-82-4 (S)-2-amino-3-cyclohexyl-(R)-1-(2-furanyl)propan-1-ol 
• 133660-68-1 N--(S)-2-amino-3-cyclohexyl-(R)-1-(2-furanyl)propan-1-ol 
• 143226-26-0 2-amino-4,7-anhydro-1-cyclohexyl-1,2,5,6-tetradeoxy-L-arabino-heptitol 
• 143233-22-1 4,7-anhydro-2-carboxyamino-1-cyclohexyl-1,2,5,6-tetradeoxy-L-arabino-heptitol γ lactone 
• 143293-00-9 4,7-anhydro-2-carboxyamino-1-cyclohexyl-1,2,5,6-tetradeoxy-D-xylo-heptitol γ lactone 
• 150593-85-4 2-carboxamino-1-cyclohexyl-1,2,4,5,6,7-hexadeoxy-4,7-epithio-L-arabino-heptitol, intramol-2,3-ester 
• 152426-25-0 2-carboxamino-1-cyclohexyl-1,2,4,5,6,7-hexadeoxy-4,7-epithio-D-xylo-heptitol, intramol-2,3-ester 
• 150593-82-1 <4S-<4α,5β(S^*)>>-5-(4-bromo-1-hydroxybutyl)-4-cyclohexylmethyl-2-oxazolidinone 
• 152426-27-2 <4S-<4α,5β(R^*)>>-5-(4-bromo-1-hydroxybutyl)-4-cyclohexylmethyl-2-oxazolidinone 
• 150593-83-2 2-carboxyamino-1-cyclohexyl-1,2,5,6-tetradeoxy-7-thio-D-xylo-heptitol-7-acetate, intramol-2,3-ester 
• 152426-28-3 2-carboxyamino-1-cyclohexyl-1,2,5,6-tetradeoxy-7-thio-L-arabino-heptitol-7-acetate, intramol-2,3-ester 
• 152426-29-4 Thioacetic acid S-[(S)-4-((4S,5R)-4-cyclohexylmethyl-2-oxo-oxazolidin-5-yl)-4-methanesulfonyloxy-butyl] ester 

Relevant academic research and scientific papers

THE SYNTHESIS OF HETEROCYCLIC C-TERMINAL UNITS WHICH MIMIC THE TRANSITION STATE IN THE CLEAVAGE OF THE LEU-VAL BOND OF ANGIOTENSINOGEN BY RENIN

The stereospecific synthesis of (S)2-amino-3-cyclohexyl-(R)1-(2-furanyl)-propan-1-ol (17) and (S)2-amino-3-cyclohexyl-(R)1-(2-thienyl)-propan-1-ol (18) from t-Boc-L-phenylalanine is described.Reduction of the furan ring of (4S-trans)-4-(cyclohexylmethyl)-

RENIN INHIBIOTRS

Renin inhibiting compounds containing a single α-amino acid of the formula: STR1 and analogs thereof which inhibit the substrate-cleaving acting or renin, pharmaceutical compositions containing these compounds, processes for producing the compounds and methods of treating hypertension which employ the novel renin inhibitors.

RENIN INHIBITORS

The invention is new renin inhibitor dipeptide and tripeptide derivatives of the formula: STR1

N-phosphinyl di-and tripeptides as renin inhibitors.

The invention concerns new renin inhibitor dipeptide and tripeptide derivatives of the formula:*(formula 01)* in which the meaning of all the symbols Rn and A is described in the text.