13349-87-6Relevant academic research and scientific papers
Iron(II)-Based Metalloradical Activation: Switch from Traditional Click Chemistry to Denitrogenative Annulation
Roy, Satyajit,Khatua, Hillol,Das, Sandip Kumar,Chattopadhyay, Buddhadeb
supporting information, p. 11439 - 11443 (2019/07/17)
A unique concept for the intermolecular denitrogenative annulation of 1,2,3,4-tetrazoles and alkynes was discovered by using a catalytic amount of Fe(TPP)Cl and Zn dust. The reaction precludes the traditional, more favored click reaction between an organic azide and alkynes, and instead proceeds by an unprecedented metalloradical activation. The method is anticipated to advance access to the construction of important basic nitrogen heterocycles, which will in turn enable discoveries of new drug candidates.
Fused tetrazoles as azide surrogates in click reaction: Efficient synthesis of N-heterocycle-substituted 1,2,3-triazoles
Chattopadhyay, Buddhadeb,Vera, Claudia I. Rivera,Chuprakov, Stepan,Gevorgyan, Vladimir
supporting information; experimental part, p. 2166 - 2169 (2010/08/05)
Figure presented It has been shown that various pyrido-, quinolino-, pyrazino-, and quinoxalinotetrazoles can be used efficiently as azide components in Cu-catalyzed click reaction with alkynes. This method allows for efficient synthesis of a wide variety
