133496-58-9Relevant academic research and scientific papers
Chemoenzymatic synthesis and binding affinity of novel (R)- and (S)-3-aminomethyl-1-tetralones, potential atypical antipsychotics
Caro, Yolanda,Torrado, Maria,Masaguer, Christian F.,Ravina, Enrique,Padin, Fernando,Brea, Jose,Loza, Maria I.
, p. 585 - 589 (2007/10/03)
A series of (R)- and (S)-3-aminomethyl-1-tetralones, conformationally constrained analogues of haloperidol, have been obtained by enzymatic resolution of the corresponding racemic 3-hydroxymethyl-1-tetralones using Pseudomonas fluorescens lipase. Their bi
Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone
Cortizo,Santana,Ravina,Orallo,Fontenla,Castro,Calleja,De Ceballos
, p. 2242 - 2247 (2007/10/02)
Starting from β-benzoylpropionic acid we synthesized 3-(aminomethyl)tetralones in which the amino substituent was 4-(N-piperazinyl)-p-fluorobutyrophenone (14), 4-benzoylpiperidine (15), 4-hydroxy-4-phenylpiperidine (16) or 4-(o-methoxyphenyl)piperazine (1
