13350-09-9

Usage

Nitro-substituted propargyloxybenzene

A type of chemical compound in which a nitro group (-NO2) is attached to a propargyloxybenzene (a benzene ring with a propargyl ether functional group).

Nitro group

A functional group consisting of an oxygen atom and a nitrogen atom (-NO2), which is known to impart explosive properties and can participate in various chemical reactions.

Propargyl ether functional group

A functional group with a triple-bonded carbon atom connected to an oxygen atom and an alkyl group (in this case, a propargyl group), which can undergo addition reactions and other chemical transformations.

Building block in organic synthesis

1-nitro-2-prop-2-ynyloxy-benzene is commonly used as an intermediate compound in the synthesis of more complex organic molecules, providing a versatile starting point for various chemical reactions.

Unique structure

The presence of both a nitro group and a propargyl ether functional group attached to a benzene ring gives 1-nitro-2-prop-2-ynyloxy-benzene a distinctive structure that allows for diverse chemical reactions and applications.

Precursor in the preparation of various organic compounds

1-nitro-2-prop-2-ynyloxy-benzene serves as a starting material for the synthesis of a wide range of organic compounds, making it an important reagent in organic chemistry.

Versatility and utility

The compound's unique structure and reactivity make it valuable in the field of organic chemistry, as it can be used to create a variety of other compounds with different properties and applications.

Upstream product

• 6165-75-9 propargyl benzenesulfonate 
• 88-75-5 2-hydroxynitrobenzene 
• 13610-02-1 1-phenoxy-2-propyne 
• 106-96-7 propargyl bromide 
• 107-19-7 propargyl alcohol 
• 1493-27-2 ortho-nitrofluorobenzene 
• 104493-07-4 3-(triisopropylsilyl)propargyl alcohol 

Downstream Products

• 113714-08-2 5-(2-Nitro-phenoxymethyl)-1-phenyl-1H-[1,2,3]triazole 
• 113714-07-1 4-(2-Nitro-phenoxymethyl)-1-phenyl-1H-[1,2,3]triazole 
• 52536-39-7 2-(prop-2-ynyloxy)benzenediazonium tetrafluoroborate 
• 79718-49-3 (NO₂C₆H₄OCH₂CC)2Hg 
• 1144040-23-2 1-[2-(2-methyl-5-nitro-imidazol-1-yl)-ethyl]-4-(2-nitro-phenoxymethyl)-1H-[1,2,3]triazole 
• 1286164-80-4 1-benzyl-4-[(2-nitrophenoxy)methyl]-1,2,3-triazole 
• 1365258-91-8 2-methyl-5-((4-((2-nitrophenoxy)methyl)-1H-1,2,3-triazol-1-yl)methyl)pyrimidin-4-amine 
• 1485820-31-2 C₁₄H₁₃N₇O₅ 
• 1485821-41-7 C₁₅H₁₅N₇O₅ 
• 1485822-51-2 C₁₆H₁₇N₇O₅ 

Relevant academic research and scientific papers

Efficient synthesis of new antiproliferative steroidal hybrids using the molecular hybridization approach

A series of steroidal hybrids with different terminal bioactive scaffolds were synthesized using the molecular hybridization approach and further evaluated for their antiproliferative activity against several cancer cell lines of different origins using t

Facile assembly of Bodipy-based metal ion sensor using click chemistry

In this study, two novel 4,4′-difluoro-4-bora-3a,4a-diaza-s-indacenes (BODIPY)-based metal ion sensors were synthesised using click chemistry. The coordination modes and binding constants of the complexes formed with a range of metal ions were calculated.

A click chemistry strategy to synthesize geraniol-coupled 1,4-disubstituted 1,2,3-triazoles and exploration of their microbicidal and antioxidant potential with molecular docking profile

The present paper elicits an unprecedented synthesis of a novel series of 1,2,3-triazole compounds using geraniol as the precursor via 1,3-dipolar cycloaddition using click chemistry strategy. All the synthesized compounds were screened to evaluate their

Design, synthesis and biological evaluation of novel triazole-core reversal agents against P-glycoprotein-mediated multidrug resistance

We designed and synthesized a novel series of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) inhibitors bearing a triazolphenethyl-tetrahydroisoquinoline scaffold through click chemistry. Then those synthesized compounds were tested on doxorubi

Synthesis of sorafenib analogues incorporating a 1,2,3-triazole ring and cytotoxicity towards hepatocellular carcinoma cell lines

A series of 1,2,3-triazole-containing Sorafenib analogues, in which the aryl urea moiety of Sorafenib (1) was replaced with a 1,2,3-triazole ring linking a substituted phenoxy fragment, were prepared successfully via Huisgen 1,3-dipolar cycloaddition and

Novel ferrocene-based 1,2,3-triazolyl compounds: Synthesis, anti-migration properties and catalytic effects on oxidizers during combustion

To tackle high-migratory and high-volatility problem of marketed neutral ferrocene-based burning rate catalysts, twenty-one ferrocene-based 1,2,3-triazolyl compounds (Fc-TAZs) were synthesized by click reaction and characterized completely by NMR, FT-IR,

Ruthenium-Catalyzed Tandem Carbene/Alkyne Metathesis/N-H Insertion: Synthesis of Benzofused Six-Membered Azaheterocycles

The Cp*RuCl-based catalyst enables expedient access to a variety of benzofused six-membered azaheterocycles from unprotected o-alkynylanilines and trimethylsilyldiazomethane through an unprecedent tandem carbene/alkyne metathesis/N-H insertion reaction. The transformation takes place under mild reaction conditions (room temperature, 15 min) and with excellent functional group tolerance. The synthetic utility of the final products and a mechanistic rationale are also discussed.

Synthesis and bioactivities evaluation of novel vv-pyridylpyrazole derivatives with 1,2,3-triazole and quinazolin-4(3H)-one substructures

Two series of JV-pyridylpyrazole derivatives containing 1,2,3-triazole and quinazolin-4(3H)-one substructures were designed and synthesized. In total, 18 novel compounds were prepared, and all compounds were characterized by 1H NMR, 13C NMR and elemental

AgNO3Catalyzed Regio-Selective Synthesis of 3-Alkyl/Aryl-idene-3,4-dihydro-4-tosyl-2H-1,4-Benzoxazine: Novel Anti-Tubercular Scaffolds

A facile and efficient method for the construction of 3-alkyl/aryl substituted 1,4-benzoxazine and benzoxazepine via AgNO3catalyzed cyclization of propargyloxy sulfonamides and their anti-tubercular activity against Mycobacterium tuberculosis H37RVis described. This cyclization proceeds through 6-exo-dig manner to generate the products in moderate to good yields.

Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors

A novel series of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) inhibitors with triazol-N-phenethyl-tetrahydroisoquinoline or triazol-N-ethyl-tetrahydroisoquinoline scaffold were designed and synthesized via click chemistry. Most of the synthesized compounds showed higher reversal activity than verapamil (VRP). Among them, the most potent compound 4 showed a comparable activity with the known potent P-gp inhibitor WK-X-34 with lower cytotoxicity toward K562 cells (IC50 >100 μM). Compared with VRP, compound 4 exhibited more potency in increasing drug accumulation in K562/A02 MDR cells. Moreover, compound 4 could significantly reverse MDR in a dose-dependent manner and also persist longer chemo-sensitizing effect than VRP with reversibility. Further mechanism studies revealed that compound 4 could remarkably increase the intracellular accumulation of Adriamycin (ADM) in K562/A02 cells as well as inhibit rhodamine-123 (Rh123) efflux from the cells. These results suggested that compound 4 may represent a promising candidate for developing P-gp-mediated MDR inhibitors.