1335002-96-4Relevant academic research and scientific papers
Development of 6-[18F]fluoro-carbohydrate-based prosthetic groups and their conjugation to peptides via click chemistry
Collet, Charlotte,Maskali, Fatiha,Clément, Alexandra,Chrétien, Fran?oise,Poussier, Sylvain,Karcher, Gilles,Marie, Pierre-Yves,Chapleur, Yves,Lamandé-Langle, Sandrine
, p. 54 - 62 (2016)
This work describes the development of new 6-[18F]fluoro-carbohydrate-based prosthetic groups equipped with an azido arm that are able to participate in copper(I)-catalyzed cycloadditions for 18F labeling of biomolecules under mild c
Carbohydrate-based crosslinking agents: Potential use in hydrogels
Paterson, Stefan M.,Clark, Jasper,Stubbs, Keith A.,Chirila, Traian V.,Baker, Murray V.
, p. 4312 - 4315 (2011)
A bis(methacrylamido) derivative of glucose has been used as a crosslinking agent for PHEMA sponges formed by polymerization-induced phase separation. Copyright
Click glycosylation of peptides through cysteine propargylation and CuAAC
Lamandé-Langle, Sandrine,Collet, Charlotte,Hensienne, Rapha?l,Vala, Christine,Chrétien, Fran?oise,Chapleur, Yves,Mohamadi, Amel,Lacolley, Patrick,Regnault, Véronique
, p. 6672 - 6683 (2014)
'Click' glycosylation of cysteine-containing peptides were carried out in good yield by Copper(I)-catalyzed Azide-Alkyne Cycloaddition (CuAAC). For that peptides were functionalized though direct propargylation of the cysteine residue allowing their use in CuAAC with suitable free or protected azido sugars of gluco, manno and galacto configuration. Among these free and protected glycopeptides a series of 'glycoRGD' peptides were obtained and submitted to in vitro platelet aggregation tests, showing that the pseudoglycosylation of the adhesion sequence lowers the IC50 value and thus could improve the in vivo pharmacokinetic properties.
