1335008-89-3

Upstream product

• 90-24-4 2-hydroxy-4,6-dimethoxyacetophenone 
• 621-23-8 1,2,3-trimethoxybenzene 
• 18064-89-6 1-(3-bromo-2-hydroxyl-4,6-dimethoxyphenyl)ethanone 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 64200-22-2 (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel series of chalcone derivatives as inhibitors of cyclooxygenase and LPS-induced TNF-α with potent antioxidant properties

Novel series of chalcones were synthesized and were evaluated as possible anti-inflammatory agents targeting the cyclooxygenase-1 and 2 (COX-1 and 2), β-glucuronidase, trypsin, and TNF-α. Amongst the tested chalcones the compound 4k was found to be most effective inhibitor of TNF-α exhibiting 85% inhibition activity (IC50 = 0.1 μM). The compounds 4a, 4f, 4l, and 4m were found to inhibit the COX-1 activity in as a range of 79.95-68.47% and COX-2 inhibition ranging 84.45-74.77%. The compounds 4l (81.71%) and 4f (72.10%) were found to be excellent inhibitors of trypsin and β-glucuronidase, respectively. Springer Science+Business Media, LLC 2011.

Regioselective monobromination of (E)-1-(2′-hydroxy-4′, 6′-dimethoxyphenyl)-3-aryl-2-propen-1-ones using bromodimethylsulfonium bromide and synthesis of 8-bromoflavones and 7-bromoaurones

A wide variety of monobrominated compounds 2a-l have been prepared in good yields from (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-aryl-2- propen-1-ones (1a-l) through regioselective ring bromination using 1.5 equiv of bromodimethylsulfonium bromide (BDMS)