1335009-24-9Relevant academic research and scientific papers
Synthesis and biological evaluation of novel series of chalcone derivatives as inhibitors of cyclooxygenase and LPS-induced TNF-α with potent antioxidant properties
Bandgar, Babasaheb P.,Hote, Baliram S.,Dhole, Nagesh A.,Gacche, Rajesh N.
, p. 2292 - 2299 (2012/11/06)
Novel series of chalcones were synthesized and were evaluated as possible anti-inflammatory agents targeting the cyclooxygenase-1 and 2 (COX-1 and 2), β-glucuronidase, trypsin, and TNF-α. Amongst the tested chalcones the compound 4k was found to be most effective inhibitor of TNF-α exhibiting 85% inhibition activity (IC50 = 0.1 μM). The compounds 4a, 4f, 4l, and 4m were found to inhibit the COX-1 activity in as a range of 79.95-68.47% and COX-2 inhibition ranging 84.45-74.77%. The compounds 4l (81.71%) and 4f (72.10%) were found to be excellent inhibitors of trypsin and β-glucuronidase, respectively. Springer Science+Business Media, LLC 2011.
