1335015-59-2

Basic information

• Product Name: 2-(4-(4-(4-nitrophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one
• Synonyms: 2-(4-(4-(4-nitrophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one
• CAS NO: 1335015-59-2
• Molecular Weight: 519.538
• Mol File: 1335015-59-2.mol

Chemical Properties

• CAS DataBase Reference: 2-(4-(4-(4-nitrophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(4-(4-nitrophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one(1335015-59-2)
• EPA Substance Registry System: 2-(4-(4-(4-nitrophenylsulfonyl)piperazine-1-carbonyl)phenyl)quinazolin-4(3H)-one(1335015-59-2)

Safety Data

• Hazardous Substances Data: 1335015-59-2(Hazardous Substances Data)

Upstream product

• 28144-70-9 anthranilic acid amide 
• 1679-64-7 Monomethyl terephthalate 
• 1335014-09-9 2-(4-(piperazine-1-carbonyl)phenyl) quinazolin-4(3H)-one 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 925136-87-4 4-(2-carbamoylphenylcarbamoyl)benzoic acid methyl ester 
• 1335014-00-0 tert-butyl 4-(4-(4-oxo-3,4-dihydroquinazolin-2-yl)benzoyl)piperazine-1-carboxylate 
• 374711-37-2 4-(4-oxo-3,4-dihydroquinazolin-2-yl)benzoic acid 

Relevant articles and documents

Synthesis and cytotoxicity of 2-phenylquinazolin-4(3H)-one derivatives

Thirty 2-phenylquinazolin-4(3H)-one derivatives were prepared and their cytotoxic activities were tested in five human tumor cell lines. Some compounds (5e, 5k, 5t, 6c and 6f) showed relatively high cytotoxic activity. Especially, compound 6c showed the most cytotoxicity against all cell lines tested among the synthesized derivatives, and the inhibitory activity of 6c against HeLa cell was higher than that of adriamycin. The putative mechanism of antitumor action in apoptotic cell death was cell cycle arrest in the G0/G1 phase by compounds 5k, 5v, 5m, 6c, and 6f in HeLa cells. These compounds showed relatively high cytotoxicity in this cell type.