1335093-95-2

Upstream product

• 621-59-0 isovanillin 
• 1335093-93-0 2-(2-fluoroethoxy)-1-methoxy-4-(1-methoxy-2-nitroethyl)benzene 
• 1335093-91-8 (E)-2-(2-fluoroethoxy)-1-methoxy-4-(2-nitrovinyl)benzene 

Downstream Products

• 1335093-55-4 1-(3-fluoro-4-methoxybenzyl)-6-(2-fluoroethoxy)-7-methoxyisoquinoline oxalate 
• 1335093-56-5 6-(2-fluoroethoxy)-7-methoxy-1-(4-methoxy-3-methylbenzyl)-isoquinoline oxalate 
• 1335093-57-6 6-(2-fluoroethoxy)-7-methoxy-1-(4-(methylthio)benzyl)isoquinoline oxalate 
• 1335093-37-2 1-(3-fluoro-4-methoxybenzyl)-6-(2-fluoroethoxy)-7-methoxyisoquinoline 
• 1335093-38-3 6-(2-fluoroethoxy)-7-methoxy-1-(4-methoxy-3-methylbenzyl)-isoquinoline 
• 1335093-39-4 6-(2-fluoroethoxy)-7-methoxy-1-(4-(methylthio)benzyl)isoquinoline 
• 1335093-74-7 N-(2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-2-methoxyethyl)-2-(4-(methylthio)phenyl)acetamide 
• 1335093-73-6 N-(2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-2-methoxyethyl)-2-(4-methoxy-3-methylphenyl)acetamide 
• 1335093-72-5 2-(3-fluoro-4-methoxyphenyl)-N-(2-(3-(2-fluoroethoxy)-4-methoxyphenyl)-2-methoxyethyl)acetamide 

Relevant academic research and scientific papers

Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A

A series of analogues were synthesized by optimizing the structure of papaverine. The in vitro PDE10A binding affinity (IC50) values for these new analogues were measured; for compounds that have IC50 value less than 60 nM for PDE10A