1335113-27-3Relevant academic research and scientific papers
Fluoro-substituted ketones from nitriles using acidic and basic reaction conditions
Raja, Erum K.,Klumpp, Douglas A.
supporting information; experimental part, p. 5170 - 5172 (2011/10/13)
Fluoro-substituted aliphatic nitriles are shown to undergo the Houben-Hoesch reactions with arenes in CF3SO3H to give fluoro-substituted ketones in good yields. The fluorine substituents appear to enhance the reactivities of the nitriles (and the nitrilium ion intermediates) compared to similar aliphatic nitriles. Fluoro-substituted ketones are also shown to be accessible through the reactions of organometallic reagents and fluoro-substituted nitriles.
