1335138-67-4

Upstream product

• 1335139-72-4 methyl (2S)-5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate 
• 1164116-60-2 1-[(chlorocarbonyl)oxy]ethyl 2-methylpropionate 
• 1335138-62-9 (2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid 
• 1335139-07-5 dimethyl 2-(3-((tert-butoxycarbonyl)amino)propyl)malonate 
• 1335139-06-4 5-[(tert-butoxycarbonyl)amino]-2-(methoxycarbonyl)valeric acid 
• 1335139-08-6 1-(trans-4-methylcyclohexyl)-1H-imidazole-4-carbaldehyde 
• 194995-47-6 1-[[(4-nitrophenoxy)carbonyl]oxy]-2-methylpropionic acid ethyl ester 
• 1335144-15-4 methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate 
• 1335139-10-0 [1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methanol 
• 1335139-09-7 ethyl 1-(trans-4-methylcyclohexyl)-1H-imidazole-4-carboxylate 
• 2523-55-9 trans-4-methylcyclohexanamine 

Downstream Products

• 1335138-68-5 1-[(isopropoxycarbonyl)oxy]ethyl (2S)-5-({[1-(isobutyryloxy)ethoxy]carbonyl}amino)-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate 

Relevant academic research and scientific papers

METHOD FOR PRODUCING 1-(ACYLOXY)ALKYL CARBAMATE DERIVATIVE

A method for producing a 1-(acyloxy)alkyl carbamate derivative (III), using a fluorous alkyl carbonate derivative (I), and a fluorous alkyl carbonate derivative (I) and a method for producing the same. In the formula, R1 represents C1-C4 alkyl group or a C3-C6 cycloalkyl group, R2 represents a C1-C4 alkyl group or a hydrogen atom, and A represents a fluorous alkyl group (wherein the fluorous alkyl group represents a C2-C11 alkyl group in which 40% or more of the hydrogen atoms are replaced by fluorine atoms).

CYCLOALKYL-SUBSTITUTED IMIDAZOLE DERIVATIVE

A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein A represents a C3 to C12 cycloalkyl group which may be substituted by one to three selected from a fluoro group, a hydroxy group, a C1 to C6 alkyl group, etc; R1, R2, and R3 each independently represent a hydrogen atom, a fluoro group, or a C1 to C6 alkyl group; R4 represents a hydrogen atom or a prodrug group; and Y represents -CH2-CHR5-CH2-NHR6 (wherein R5 represents a hydrogen atom, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group, and R6 represents a hydrogen atom or a prodrug group), or the like exhibits excellent TAFIa inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, and the like.