133522-01-7

Upstream product

• 133463-12-4 1-[(S)-2-Benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-1-hydroxy-ethyl]-cyclopropanecarboxylic acid 2,6-di-tert-butyl-4-methyl-phenyl ester 
• 103795-12-6 (R)-2-(benzyloxy)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]acetaldehyde 

Downstream Products

• 133522-02-8 ((4S,6R,7S,8R)-7,8-Bis-benzyloxy-4-methoxy-5-oxa-spiro[2.5]oct-6-yl)-methanol 
• 133463-16-8 1-[(1R,2S)-1,2-Bis-benzyloxy-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-cyclopropanecarbaldehyde 

Relevant academic research and scientific papers

Synthesis of 2-spirocyclopropylglucose via condensation of erythrose with the lithium enolate of 2,6-di-tert=butyl-4-methylphenyl cyclopropanecarboxylate

Glyceraldehyde, erythrose, and threose are condensed with the enolate derived from cyclopropanecarboxylic acid BHT ester. The conversion of two diastereomeric products of this condensation into new 2-spirocyclopropyl-substituted aldopyranoses is described.