1335232-07-9

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 6343-93-7 2-(4-methoxyphenyl)acetamide 
• 60759-02-6 2-(4-methoxyphenyl)ethanethioamide 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1335232-05-7 2-(4-methoxybenzyl)-4-(4-methoxyphenyl)thiazole 

Relevant academic research and scientific papers

Cytotoxic 1,3-thiazole and 1,2,4-thiadiazole alkaloids from Penicillium oxalicum: Structural elucidation and total synthesis

Two new thiazole and thiadiazole alkaloids, penicilliumthiamine A and B (2 and 3), were isolated from the culture broth of Penicillium oxalicum, a fungus found in Acrida cinerea. Their structures were elucidated mainly by spectroscopic analysis, total synthesis and X-ray crystallographic analysis. Biological evaluations indicated that compound 1, 3a and 3 exhibit potent cytotoxicity against different cancer cell lines through inhibiting the phosphorylation of AKT/PKB (Ser 473), one of important cancer drugs target.