1335232-62-6

Basic information

• Product Name: C₁₇H₁₃Cl₂NO
• CAS NO: 1335232-62-6
• Molecular Weight: 318.202
• Mol File: 1335232-62-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₃Cl₂NO(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₃Cl₂NO(1335232-62-6)
• EPA Substance Registry System: C₁₇H₁₃Cl₂NO(1335232-62-6)

Safety Data

• Hazardous Substances Data: 1335232-62-6(Hazardous Substances Data)

Upstream product

• 106-47-8 4-chloro-aniline 
• 17722-20-2 N¹,N³-bis(4-chlorophenyl)malonamide 
• 1677-36-7 6-chloro-4-hydroxyquinolin-2(1H)-one 
• 1677-50-5 2,4,6-trichloroquinoline 
• 108-68-9 3,5-Dimethylphenol 

Downstream Products

• 1335232-63-7 6-chloro-4-(3,5-dimethylphenoxy)quinolin-2(1H)-one 

Relevant articles and documents

Synthesis of quinolin-2-one alkaloid derivatives and their inhibitory activities against HIV-1 reverse transcriptase

Based on an established common pharmacophore of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNTTIs), a series of quinolin-2-one derivatives were synthesized and assayed for their in vitro activities against HIV-1 reverse transcriptase (RT) for the first time. Some of the tested compounds were active against HIV-1 RT. Compounds 4a2 and 4d2 showed inhibitory activities with IC50 values of 0.21 and 0.15 μM, respectively, with a mode of interaction with RT residues of the allosteric pocket similar to that of efavirenz.