1335243-45-2Relevant academic research and scientific papers
Chiral sulfoxide-olefin ligands: Tunable stereoselectivity in Rh-catalyzed asymmetric 1,4-additions
Chen, Guihua,Gui, Jiangyang,Cao, Peng,Liao, Jian
, p. 3220 - 3224 (2012/06/01)
A class of chiral sulfoxide-olefins were designed and synthesized through concise routes. Their applications as ligands in Hayashi-Miyaura reaction were studied, which found that vinyl substituents of the ligands vary in stereocontrolling ability. Particularly, either isomer of adducts with excellent ees could be readily obtained through changing the position of the substituents of olefins as well as changing the configuration of the CC bond of the ligands. Meanwhile, the substrate scope of arylboronic acids and alkenes was clearly shown.
Chiral sulfoxide-olefin ligands: Completely switchable stereoselectivity in rhodium-catalyzed asymmetric conjugate additions
Chen, Guihua,Gui, Jiangyang,Li, Liangchun,Liao, Jian
supporting information; experimental part, p. 7681 - 7685 (2011/10/17)
Have it both ways: A novel class of chiral sulfoxide-olefin ligands was synthesized from a single chiral source. These ligands were evaluated in rhodium-catalyzed 1,4-additions of arylboronic acids to electron-deficient olefins, and remarkable olefin-directed reversal of stereoselectivity (up to >99 ee, R isomer; 98 ee, S isomer) was observed when the reversal ligand pair L1 (branched olefin) and L2 (linear olefin) were utilized (see scheme). Copyright
