1335248-11-7Relevant articles and documents
Efficient preparation and biological evaluation of a novel multivalency bifunctional chelator for 64Cu radiopharmaceuticals
Liu, Shuanglong,Li, Zibo,Yap, Li-Peng,Huang, Chiun-Wei,Park, Ryan,Conti, Peter S.
, p. 10222 - 10225 (2011)
A novel bifunctional chelator: The sarcophagine motif was used in the development of a novel bifunctional chelator for 64Cu radiopharmaceuticals (see figure). The high tumor-targeting efficiency and great stability of the 64Cu-BaBaSa
Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same
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, (2016/08/29)
Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula where A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC/targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.