133545-14-9Relevant academic research and scientific papers
Synthesis of Axially Chiral 2,2′-Bisphosphobiarenes via a Nickel-Catalyzed Asymmetric Ullmann Coupling: General Access to Privileged Chiral Ligands without Optical Resolution
Zuo, Ziqing,Kim, Raphael S.,Watson, Donald A.
supporting information, p. 1328 - 1333 (2021/02/01)
We report an asymmetric homocoupling of ortho-(iodo)arylphosphine oxides and ortho-(iodo)arylphosphonates resulting in highly enantioenriched axially chiral bisphosphine oxides and bisphosphonates. These products are readily converted to enantioenriched b
Avoiding the classical resolution during the synthesis of MeO-BIPHEP and 3,3′-disubstituted derivatives
Gorobets, Evgueni,Wheatley, Bronwen M. M.,Hopkins, J. Matthew,McDonald, Robert,Keay, Brian A.
, p. 3843 - 3846 (2007/10/03)
The Ullmann coupling of 1 (R = H) gives a 2:1 mixture of diastereomers 2 (R = H) in 81% yield that are easily separated by silica gel chromatography. This procedure avoids the generally cumbersome and sometimes difficult resolution step with DBTA. Similar Ullmann couplings and separation of the corresponding diastereomers are employed with other derivatives of 1 (R = OtBu, iPr, Ph, and mesityl) ultimately affording a new series of 3,3′-disubsituted-MeO-BIPHEP derivatives. The use of these new derivatives in palladium-catalyzed asymmetric Heck reaction, Pd-catalyzed polyene cyclizations and rhodium-catalyzed hydrogenations is also reported.
Chiral phosphorus compounds
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, (2008/06/13)
Novel chiral phosphorus compounds of the formula STR1 wherein R signifies lower alkyl, R1 signifies phenyl and R2 and R3 signify hydrogen or lower alkoxy, which are suitable in the form of complexes with a metal of Group VIII as catalysts for asymmetric hydrogenations and for enantioselective hydrogen displacements in prochiral allylic systems.
Axially Dissymmetric Diphosphines in the Biphenyl Series: Synthesis of (6,6'-Dimethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine) ('MeO-BIPHEP') and Analogues via an ortho-Lithiation/Iodination Ullmann-Reaction Approach
Schmid, Rudolf,Foricher, Joseph,Cereghetti, Marco,Schoenholzer, Peter
, p. 370 - 389 (2007/10/02)
The new axially dissymmetric diphosphines (R)- and (S)-(6,6'-dimethoxybiphenyl-2,2'-diyl)bis(diphenylphosphine) ((R)- and (S)-5a; 'MeO-BIPHEP') and the analogues (R)- and (S)-5b and 5c have been synthesized in enantiomerically pure form.These lignands hav
