13355-32-3

Upstream product

• 693-95-8 4-Methylthiazole 
• 624-38-4 para-diiodobenzene 
• 623-27-8 terephthalaldehyde, 
• 101939-49-5 4,4'-dimethyl-2,5,2',5'-tetrahydro-2,2'-p-phenylene-bis-thiazole 
• 13363-51-4 benzene-1,4-dithiocarboxamide 
• 78-95-5 chloroacetone 

Relevant academic research and scientific papers

Pd/Cu-cocatalyzed reigoselective arylation of thiazole derivatives at 2-position under ligand-free conditions

An efficient protocol for regioselective arylation of thiazole derivatives at the 2-position via palladium- and copper-catalyzed C-H bond activation under ligand-free conditions has been developed. The reaction proceeds smoothly with 1% palladium catalyst in the presence of 20% Cu(TFA)2 to furnish the desired products. The direct C-H arylation and no ligand made this method synthetically useful for the arylation of thiazoles at the 2-position.