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Product FOB Price Min.Order Supply Ability Supplier
Tyrphostin AG 490
Cas No: 133550-30-8
No Data No Data No Data Beijing Jin Ming Biotechnology Co., Ltd. Contact Supplier
Cas No: 133550-30-8
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
Cas No: 133550-30-8
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
Cas No: 133550-30-8
No Data 1 Kilogram 1000 Kilogram/Month Henan Tianfu Chemical Co., Ltd. Contact Supplier
Factory direct supply CAS 133550-30-8 with best quality
Cas No: 133550-30-8
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
Cas No: 133550-30-8
No Data No Data 10000 Metric Ton/Month Henan Wentao Chemical Product Co., Ltd. Contact Supplier
AG 490
Cas No: 133550-30-8
USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 1000 Metric Ton/Day Hebei Guanlang Biotechnology Co., Ltd. Contact Supplier
AG 490
Cas No: 133550-30-8
No Data 1 Gram 1000 Gram/Week Shanghai BetterBioChem Co., Ltd. Contact Supplier
R&D AG 490 133550-30-8 Lab reaearch/ custom synthesis impurities
Cas No: 133550-30-8
USD $ 500.0-500.0 / Milligram 1 Milligram 100 Gram/Week Shandong Bolode Bio-Technology Co., LTD Contact Supplier
Cas No: 133550-30-8
No Data 10 Kilogram 1 Kilogram/Day HANGZHOU CLAP TECHNOLOGY CO,.LTD Contact Supplier

133550-30-8 Usage


AG-490 (133550-30-8) is a potent inhibitor of the JAK2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock.3 AG-490 is a useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes.4


AG 490 is a potent epidermal growth factor receptor kinase autophosphorylation inhibitor with an IC50 of 100 nM and 56.8 μM for EGFR and JAK, respectively.


Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity5. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells6.

Biological Activity

Selective inhibitor of EGF receptor tyrosine kinase (IC 50 values are 2 and 13.5 μ M for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent cell growth in vitro and tumor cell invasion in vivo .

Biochem/physiol Actions

Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma.


References/Citations 1) Wang et al. (1999), JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response; J. Immunol. 162 3897 2) Meydan et al. (1996), Inhibition of acute lymphoblastic leukaemia by Jak-2 inhibitor; Nature, 379 645 3) Gyurkovska and Ivanovaska (2015), Tyrosine kinase inhibitor tyrphostin AG490 reduces liver injury in LPS-induced shock; Eur. J. Pharmacol., 751 118 4) Wu et al. (2015), ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca(+2) overload and contractile dysfunction via the JAK2/STAT3 pathway; J. Mol. Cell. Cardiol., 81 150

133550-30-8 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (T2962)  Tyrphostin AG 490  >98.0%(HPLC)(T) 133550-30-8 20mg 290.00CNY Detail
TCI America (T2962)  Tyrphostin AG 490  >98.0%(HPLC)(T) 133550-30-8 100mg 890.00CNY Detail
TCI America (T2962)  Tyrphostin AG 490  >98.0%(HPLC)(T) 133550-30-8 1g 4,900.00CNY Detail
Sigma (T3434)  Tyrphostin AG 490  solid 133550-30-8 T3434-5MG 799.11CNY Detail
Sigma (T3434)  Tyrphostin AG 490  solid 133550-30-8 T3434-25MG 3,528.72CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017


1.1 GHS Product identifier

Product name Tyrphostin AG 490

1.2 Other means of identification

Product number -
Other names N-Benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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