1335544-80-3Relevant academic research and scientific papers
Synthesis of α-CF3-substituted carbonyl compounds with relative and absolute stereocontrol using electrophilic CF3-transfer reagents
Matousek, Vaclav,Togni, Antonio,Bizet, Vincent,Cahard, Dominique
, p. 5762 - 5765 (2012/01/06)
Evans-type chiral lithium imide enolates undergo diastereoselective α-trifluoromethylation with a hypervalent iodine-CF3 reagent with up to 91% combined isolated yield and 97:3 dr. The resulting isolated diastereopure products can be further transformed into valuable products without racemization.
