133560-59-5Relevant academic research and scientific papers
Synthesis of fully substituted pyrazoles via regio- and chemoselective metalations
Despotopoulou, Christina,Klier, Lydia,Knochel, Paul
supporting information; experimental part, p. 3326 - 3329 (2009/12/01)
The full functionalization of the pyrazole ring was achieved by successive regioselective metalations using TMPMgCI-LiCI and TMP2Mg.2LiCI. Trapping with various electrophiles led to trisubstituted pyrazoles. An application to the synthesis of the acaricide Tebufenpyrad is reported.
THE METHYL FUNCTION AS SUITABLE N-1 PROTECTING GROUP IN LITHIATION REACTIONS WITH PYRAZOLES AND 1,2,4-TRIAZOLES
Fugina, Natalie,Holzer, Wolfgang,Wasicky, Michael
, p. 303 - 314 (2007/10/02)
Metallation of 1-methyl-1H-pyrazole or 1-methyl-1H-1,2,4-triazole, respectively, with one equivalent of n-BuLi followed by reacrion with appropriate electrophiles leads to 5-substituted 1-2-(trimethylsi
