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133562-36-4

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133562-36-4 Usage

General Description

2-amino-1-[2-(trifluoromethyl)phenyl]ethanol, also known as flunarizine, is a chemical compound with a complex molecular structure. It is an ethanolamine derivative that contains an amino group and a trifluoromethylphenyl group. Flunarizine is often used as a calcium channel blocker and is prescribed for the treatment of various conditions including migraines, vertigo, and some neurological disorders. Its mechanism of action involves blocking calcium channels in the brain, which can help reduce the frequency and severity of migraines, as well as alleviate symptoms of vertigo. In addition, it may also have anti-inflammatory and antioxidant effects. Flunarizine is often administered orally, and its use is associated with potential side effects such as drowsiness, weight gain, and dizziness.

Check Digit Verification of cas no

The CAS Registry Mumber 133562-36-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,5,6 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 133562-36:
(8*1)+(7*3)+(6*3)+(5*5)+(4*6)+(3*2)+(2*3)+(1*6)=114
114 % 10 = 4
So 133562-36-4 is a valid CAS Registry Number.

133562-36-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-1-(2-(trifluoromethyl)phenyl)ethanol

1.2 Other means of identification

Product number -
Other names 2-Amino-1-[2-(trifluoromethyl)phenyl]ethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:133562-36-4 SDS

133562-36-4Relevant articles and documents

Synthesis, molecular modelling and CYP24A1 inhibitory activity of novel of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides

Taban, Ismail M.,Zhu, Jinge,DeLuca, Hector F.,Simons, Claire

supporting information, p. 4076 - 4087 (2017/07/05)

CYP24A1 (25-hydroxyvitamin D-24-hydroxylase) is a useful enzyme target for a range of medical conditions including cancer, cardiovascular and autoimmune disease, which show elevated CYP24A1 levels and corresponding reduction of calcitriol (the biologically active form of vitamin D). A series of (E)-N-(2-(1H-imidazol-1-yl)-2-(phenylethyl)-3/4-styrylbenzamides have been synthesised using an efficient synthetic route and shown to be potent inhibitors of CYP24A1 (IC50 0.11–0.35?μM) compared with the standard ketoconazole. Molecular modelling using our CYP24A1 homology model showed the inhibitors to fill the hydrophobic binding site, forming key transition metal interaction between the imidazole nitrogen and the haem Fe3+ and multiple interactions with the active site amino acid residues.

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase

Jarvest, Richard L.,Erskine, Symon G.,Forrest, Andrew K.,Fosberry, Andrew P.,Hibbs, Martin J.,Jones, Joanna J.,O'Hanlon, Peter J.,Sheppard, Robert J.,Worby, Angela

, p. 2305 - 2309 (2007/10/03)

High throughput screening of Staphylococcus aureus phenylalanyl tRNA synthetase (FRS) identified ethanolamine 1 as a sub-micromolar hit. Optimisation studies led to the enantiospecific lead 64, a single-figure nanomolar inhibitor. The inhibitor series shows selectivity with respect to the mammalian enzyme and the potential for broad spectrum bacterial FRS inhibition.

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