133562-45-5

Basic information

• Product Name: (R)-2-benzyloxy-2-methylbutanoic acid
• Synonyms: (R)-2-benzyloxy-2-methylbutanoic acid
• CAS NO: 133562-45-5
• Molecular Weight: 208.257
• Mol File: 133562-45-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-benzyloxy-2-methylbutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-benzyloxy-2-methylbutanoic acid(133562-45-5)
• EPA Substance Registry System: (R)-2-benzyloxy-2-methylbutanoic acid(133562-45-5)

Safety Data

• Hazardous Substances Data: 133562-45-5(Hazardous Substances Data)

Upstream product

• 37505-02-5 (R)-(-)-2-hydroxy-2-methylbutyric acid 
• 63742-15-4 (3S,8aS)-3-<(R)-bromoethyl>-3-methyl-1,4-dioxo-3,4,6,7,8,8a-hexahydro-1H-pyrrolo<2,1-c><1,4>oxazine 
• 133562-44-4 (R)-2-Benzyloxy-2-methyl-butyric acid benzyl ester 

Relevant articles and documents

Stereoelectronic Control of the Tertiary Ketol Rearrangement: Implications for the Mechanism of the Reaction Catalysed by the Enzymes of Branched-chain Amino Acid Metabolism, Reductoisomerase and Acetolactate Decarboxylase

The alkali-catalised rearrangement of (R)--3-hydroxy-3-methylpentan-2-one has been studied.Rearrangement via transition state having an anti arrangement of C-O bonds was preferred over that with a syn arrangement by a factor of 1.8:1.The result is of interest in relation to the mechanism of action of the enzymes reductoisomerase and acetolactate decarboxylase, both of which are involved in the metabolism of the branched-chain amino acids.The structure and relative configuration of the product 23 of bromolactonisation of N-methacryloyl L-proline 22 were determined by X-ray crystallographic analysis.