133565-48-7Relevant academic research and scientific papers
Synthesis of 15N omega-hydroxy-L-arginine and ESR and 15N-NMR studies for the elucidation of the molecular mechanism of enzymic nitric oxide formation from L-arginine.
Clement,Schnoerwangen,Kaempchen,Mordvintcev,Muelsch
, p. 793 - 798 (1994)
N omega-Hydroxy-L-arginine (2) was prepared by a multi-stage synthesis; the key step was the addition of hydroxylamine to the protected cyanamide 8. The presence of N-hydroxyguanidines was confirmed, above all, by 15N-NMR investigations. 15N omega-Hydroxy
Synthesis and effects on arginase and nitric oxide synthase of two novel analogues of Nω-hydroxyarginine, Nω-hydroxyindospicine and p-hydroxyamidinophenylalanine
Vadon, Sandrine,Custot, Julien,Boucher, Jean-Luc,Mansuy, Daniel
, p. 645 - 648 (2007/10/03)
Two novel amino adds, Nω-hydroxy-D,L-indospicine and p-hydroxyamidino-D.L-phenylalanine, have been synthesized in four steps from tert-butoxycarbonylglycine. Both compounds act as good inhibitors of arginase, Nω-hydroxyindospicine be
Methodology for the Preparation of N-Guanidino-Modified Arginines and Related Derivatives
Wagenaar, Frank L.,Kerwin, James F.
, p. 4331 - 4338 (2007/10/02)
Methods for the preparation of NG-modified arginines and Nδ-heterocyclic ornithines are described.The reactive cyanamide intermediate tert-butyl Nα-Boc-Nδ-cyano-L-ornithinate (2), prepared either by treatment of
Synthesis of the putative L-arginine metabolite L-N(G)-hydroxyarginine
Feldman
, p. 875 - 878 (2007/10/02)
Syntheses of L-N(G)-hydroxyarginine (1), the putative biosynthetic precursor of nitric oxide, and the 15N labelled analogs 9 and 10 using L-ornithine as the enantiopure starting material is reported.
